General Information

  • ID:  hor006078
  • Uniprot ID:  Q9YGH4
  • Protein name:  somatostatin-28
  • Gene name:  sst2
  • Organism:  Carassius auratus (Goldfish)
  • Family:  Somatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Carassius (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi , Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala , Osteoglossocephalai , Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SAESSNQLPTRVRKEGCKNFYWKGFTSC
  • Length:  28(93-120)
  • Propeptide:  MRLCELHCYLALLGLSLVLCGRCANSQLEPDLDFRHHRLLQRASATGQATQDFTKRDVEKLLSLLSIPEMEMREKGLSMAGESEDLRLEQERSAESSNQLPTRVRKEGCKNFYWKGFTSC
  • Signal peptide:  MRLCELHCYLALLGLSLVLCGRC
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Somatostatin inhibits the release of somatotropin.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  17-28
  • Structure ID:  AF-Q9YGH4-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006078_AF2.pdbhor006078_ESM.pdb

Physical Information

Mass: 370636 Formula: C140H215N41O43S2
Absent amino acids: DHIM Common amino acids: S
pI: 9.46 Basic residues: 5
Polar residues: 13 Hydrophobic residues: 6
Hydrophobicity: -96.43 Boman Index: -7431
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 27.86
Instability Index: 3876.79 Extinction Coefficient cystines: 7115
Absorbance 280nm: 263.52

Literature

  • PubMed ID:  9827009
  • Title:  Evolution of neuroendocrine peptide systems: gonadotropin-releasing hormone and somatostatin.